METTL3 MEDIATES SOX5 M6A METHYLATION IN BRONCHIAL EPITHELIAL CELLS TO ATTENUATE TH2 CELL DIFFERENTIATION IN T2 ASTHMA

METTL3 mediates SOX5 m6A methylation in bronchial epithelial cells to attenuate Th2 cell differentiation in T2 asthma

Floor Stickers Objective: Asthma, a chronic inflammatory disease in which type 2 T helper cells (Th2) play a causative role in the development of T2 asthma.N6-methyladenosine (m6A) modification, an mRNA modification, and methyltransferase-like 3 (METTL3) is involved in the development of T2 asthma by inhibiting Th2 cell differentiation.Sex determin

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Sporadic supravalvular stenosis in a young man

Supravalvar aortic stenosis (SVAS) is a form of congenital left ventricular outflow tract GOUT RELIEF (LVOT) obstruction that occurs as a localized or diffuse narrowing of the ascending aorta beyond the superior margin of the sinuses of Valsalva.SVAS is a rare progressive congenital heart defect with a higher risk of sudden cardiac death.Our patien

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